Lipopolymer Nanoparticle‐Mediated In Vivo CRISPR‐Cas9 Editing of Mrg15 Restores Mitochondrial Mitophagy to Alleviate Metabolic‐Associated Steatohepatitis
A liver‐targeted lipopolymer nanoparticle‐mediated gene editing platform is developed to enable in vivo disruption of Mrg15 by co‐delivery of Cas9 mRNA and Mrg15 sgRNA to identify Mrg15 as a disease‐relevant epigenetic regulator in MASH and highlight liver‐directed P64H LPNP/CRISPR delivery as a promising non‐viral str...