Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineag...
Y. Kim, Sonali Arora, D. Young et al.· Nature· 0 citations
Ewing sarcoma (EwS) is an aggressive malignancy of children, adolescents, and young adults driven by the EWS::FLI1 fusion oncoprotein with few effective treatment options in the relapsed or refractory setting. We validate six transmembrane epithelial antigen of the prostate 1 (STEAP1) as a fusion-regulated and clinic...
It is shown that metastasis-to-metastasis seeding is the dominant pattern of cancer spread and that increased polyclonal migration predicts poor prognosis, and that post-mortem cell-free DNA captures genomic and transcriptional heterogeneity of the subtypes, which provides a potential strategy for noninvasive assessmen...
P. Itagi, Samantha L. Schuster, Sonali Arora et al.· Nature· 0 citations
Combined BET bromodomain and DNA methyltransferase (DNMT) inhibition was more effective than single-agent treatment in suppressing growth of TP53/RB1-loss models exhibiting a stem-like or NEPC program.
W. Storck, Diana Flores, A. Kumaraswamy et al.· JCI Insight· 0 citations
A pro-tumorigenic IL-1β/IL-6 signaling circuit mediated through local macrophages and fibroblasts is identified that unleashes the full oncogenic potential of a cancer driver activated at the PIN stage, with implications for TME-specific targeted therapeutics in early-stage disease.
Young-Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz et al.· bioRxiv· 0 citations
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