HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.
Using CRISPR-Cas9 gene editing in human pluripotent stem cells, HOPX is identified as an important regulator of oRG-like cell maintenance and the neurogenic-gliogenic balance, providing insight into the molecular programs governing human neural progenitor expansion.
Xiao-Xue Dong, Wendy W. Y. Choi, Mai Ahmed et al.
· Stem Cell Reports · 0 citations