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Author

Michael P. Gustafson

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Review Open access Aug 2026

A proposal of good manufacturing practices (GMP) laboratory for CAR T-cell therapy in Latin America and the Caribbean: challenges and opportunities

This model advocates for decentralized, modular cleanroom facilities that integrate fully closed automated manufacturing platforms with risk-based quality management systems and emphasizes the strategic implementation of artificial intelligence (AI) and digital health tools—such as electronic batch records and predicti...

S. Cabrera-Salcedo, L. Parra-Lara, Mónica Fernandes-Pineda et al. · 0 citations
#protein folding Open access Sep 2026

Engineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation

Self-assembling mRNA origami (mRNA-OG), a class of unimolecular RNA nanostructures that encode protein-coding sequences within higher-order, programmable, and compact nucleic acid architectures, is developed and established as a new design parameter for mRNA therapeutics that can affect its functionality, delivery prop...

Mark D. Knappenberger, S. J. Henry, Archana Kikla et al. · 0 citations

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