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Author

Michael T. Lam

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Open access Sep 2026

Effect of IL-4RαR576 polymorphism on response to dupilumab in asthma, a genotype-stratified, randomized, placebo- controlled trial (IDEA Trial): Design, Rationale, Methods, Strategies, and Lessons Learned

Background: Asthma is a heterogeneous chronic disease, disproportionately affecting racial and ethnic minorities, with persistence and severity influenced by both environmental and genetic factors. The IL-4RαR576 variant occurs more commonly in racially minoritized, and the genotype, independent of race, is associated...

W. Phipatanakul, Elliot Israel, D. Mauger et al. · 0 citations
Review Sep 2026

Pumping the brakes: immune checkpoints as regulators of immunity and targets of cancer therapy.

An overview of the immunologic mechanisms and clinical features of irAEs is provided, discussing how the CTLA-4 and PD-1/PD-L1 immune checkpoints help maintain immune balance, and how their blockade results in unchecked immune activation.

Musaab Alhezam, Michael T. Lam, Seigo Okada et al. · 0 citations

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