Diabetic wounds are a class of chronic non-healing wounds driven by multiple interacting factors. Conventional therapies remain limited in their ability to actively modulate the wound microenvironment and promote coordinated tissue regeneration. In this context, naturally derived biomaterials with combined biological a...
Zhi-Xuan Xiao, Xian Jiang, Yue-Shui Zhao et al.· Journal of Biomaterials Scie...· 0 citations
Lactate and lactate-mediated protein lactylation are no longer viewed merely as accompanying phenomena of enhanced glycolysis, hypoxic responses, or tissue acidification. They are now recognized as an important regulatory axis that links local metabolic stress to chromatin regulation and altered protein function. With...
The mechanisms involved in NK cells in ovarian cancer treatment, the current status of clinical applications, and new research strategies in the future are summarized to provide a reference for the development of research and clinical practice in this field.
Wei-Hong Long, Cai-Yun Zhang, Can Zhang et al.· InflammoPharmacology· 0 citations
It is highlighted that dysregulated mitophagy and mitochondrial fragmentation promote lipid accumulation and inflammation, whereas the abnormal formation of mitochondria-associated membranes (MAMs) exacerbates calcium overload and oxidative stress, and short-chain fatty acids and bile acids derived from the gut differe...
Jing-Wen Liu, Ke-Wei Li, Yinggui Deng et al.· Pharmacological Research· 0 citations
The molecular mechanisms underlying NAT10-mediated RNA ac4C modification and protein acetylation, as well as their biological functions across physiological and pathological contexts, are systematically summarized, with the aim of facilitating its clinical translation.
Chengyu Zhang, Jin Lu, Lu Tang et al.· Cell Biology and Toxicology· 0 citations
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