Mirza R. Baig

Sirtuin 1-microRNA regulatory networks in liver diseases: Mechanistic convergence, cellular senescence, and translational implications.

Metabolic dysfunction-associated steatotic liver disease, hepatotoxicity, liver fibrosis, and hepatocellular carcinoma are stages of chronic liver injury that occur in the setting of complex interactions of the various factors, including metabolic dysregulation, inflammation, oxidative stress, and cellular senescence....

Integrating resting-state functional connectivity, mismatch negativity, and auditory steady-state responses reveals convergent neurophysiological biomarkers of schizophrenia

HTLV-1 and ATL: Decoding Molecular Pathogenesis for Next-Generation Therapies.

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-lymphocyte malignancy arising as a late consequence of human T-cell leukemia virus type 1 (HTLV-1) infection. Despite decades of research, ATL remains characterized by a dismal prognosis and high relapse rates, representing a significant clinical challenge. This r...

NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.

The molecular mechanisms by which NRF2 regulates ferroptosis, including KEAP1-NRF2 signaling, metabolic rewiring, iron homeostasis, lipid remodeling, and crosstalk with p53 and other stress-response pathways are summarized.

AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.

Gen silencing studies demonstrate that AEG-1 knockdown reduces proliferation, promotes apoptosis, and enhances sensitivity to chemotherapeutic agents such as cisplatin, doxorubicin, and temozolomide, and support its potential as a target for combinatorial therapeutic strategies to improve outcomes in aggressive brain a...

Decellularized extracellular matrix bioinks through a polymer engineering lens: tissue-source-dependent macromolecular architecture, crosslinking chemistry, rheological behavior, and 3D bioprinting performance.

A polymer engineering perspective provides a more mechanistically useful basis for dECM bioink design than biological fidelity alone, and matching tissue-specific matrix composition, crosslinking architecture, rheological behavior, and printing parameters is essential for advancing dECM-based constructs toward clinical...

Extracellular Vesicles in Neurodegenerative Diseases: A New Frontier in Diagnosis and Therapy.

The biogenesis, classification, isolation methods, and molecular content of EVs are reviewed, and their role in the pathogenesis, diagnosis, and treatment of the most important neurodegenerative diseases is analyzed.

Comprehensive in silico genomics analysis of global trends and host-specific emergence of aminoglycoside resistance in Staphylococcus aureus: a One-Health perspective

The global resistome is mapped to map the global resistome, quantify temporal and host-specific trends, and assess the association between genetic determinants and phenotypic resistance by analyzing over 110,000 S. aureus genomes.

Regulatory roles of pyroptosis-associated lncRnas in breast cancer progression and immune microenvironment.

Clinical translation remains limited by dependence on retrospective transcriptomic datasets, insufficient mechanistic validation, lack of standardized assays, and scarce prospective clinical evidence, but pyroptosis-associated lncRNAs represent a promising link between tumor progression and immune regulation, with cons...

Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes

Challenges such as scalable production, cargo heterogeneity, and regulatory considerations remain, but ongoing advances in exosome engineering and patient-derived vesicles are poised to overcome these barriers.