Aug 2026· DARU Journal of Pharmaceutical Sciences· Vol 34· 0 citations· 225 references
Medicine
TL;DR
Challenges such as scalable production, cargo heterogeneity, and regulatory considerations remain, but ongoing advances in exosome engineering and patient-derived vesicles are poised to overcome these barriers.
Small interfering RNA (siRNA) therapeutics have emerged as a transformative approach for sequence-specific gene silencing, offering the potential to treat a broad spectrum of diseases by selectively suppressing disease-associated genes. However, the clinical translation of siRNA remains limited by rapid enzymatic degra...
G. S. Amrish Varshan, S. Namasivayam· Nanomedicine: Nanotechnology...· 0 citations
This review comprehensively summarized the design principles and functional characteristics of TME-responsive siRNA delivery nanocarriers, with a focus on five major stimuli: pH, hypoxia, enzymes, glutathione (GSH), and reactive oxygen species (ROS).
Xiao-Xia Zhu, Gong-Hu Zhang, Lin Li et al.· International Journal of Nan...· 1 citation
Overall, siRNA-based strategies may play a crucial role in the future development of precision-oriented therapeutic frameworks in GC research, and this review emphasizes the integration of molecular target selection with delivery system design in a GC-specific context.
Gheysar Seifollahnezhad, B. Erdağ· Experimental oncology· 0 citations
These findings support GE11-599 as a promising siRNA delivery platform for targeting EGFR-expressing cancers and enhance cell-specific internalization and endosomal escape of siRNA in GBM cells, resulting in increased siRNA bioactivity and functional gene silencing.
Jessica R. Boulos, Karen Russi, Jordan Kinnitt et al.· Pharmaceutics· 0 citations
The goal of this review is to outline a realistic pathway featuring proof-of-concept research, through discoveries to the creation of manufacturable, safe, and effective exosome/CRISPR therapeutics that can trigger durable therapeutic responses in resistant malignancies.
D. E. Uti· Experimental Cell Research· 0 citations
Overall, nanoparticle-enabled miRNA therapeutics represent a promising platform for advancing precision medicine and next-generation personalized treatment strategies for breast cancer.
Övünç Efe Lukumci, D. Cansaran-Duman, Pelin Mutlu· International Journal of Nan...· 0 citations
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