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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Mohamed Alsharif

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Review Open access Oct 2026

Patient‐Derived Organoids in Functional Precision Oncology: Tumor Modeling, Drug‐Response Prediction, and Clinical Translation

Patient‐derived organoids (PDOs) have emerged as an effective experimental platform for bridging the long‐standing gap between traditional in vitro cancer models and the biological complexity of actual tumors. These three‐dimensional cultures (3D), derived directly from patient tissues, preserve essential architectural...

Abdullah Jabri, Mohamed Alsharif, Abdulaziz Mhannayeh et al. · 0 citations
Review Open access Oct 2026

GLP-1 receptor agonists as potential disease-modifying agents in Parkinson’s and Alzheimer’s disease: mechanisms, clinical trial evidence, and the neuroprotection horizon

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), originally developed as antidiabetic agents, have emerged as candidate disease-modifying therapies for Parkinson’s disease (PD) and Alzheimer’s disease (AD), reflecting the widespread expression of GLP-1 receptors across neurons, glia, and the cerebral vasculatur...

Mohamed Alsharif, Omran Shrebaty, Mohammad Ammar Aloudah et al. · 0 citations
Review Jul 2026

Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in sickle cell disease: a narrative review of safety, engraftment, and graft-versus-host-disease outcomes in adults and high-risk populations.

The data support NMA and RIC transplantation as genuinely curative options carrying an acceptable risk profile for adults living with SCD, and advances in haploidentical conditioning have largely put to rest the graft failure rates that once made unrelated or mismatched transplantation prohibitive.

G. Elgohary, Mohamed Alsharif, R. El Fakih et al. · 0 citations

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