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Review

Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in sickle cell disease: a narrative review of safety, engraftment, and graft-versus-host-disease outcomes in adults and high-risk populations.

G. Elgohary Mohamed Alsharif R. El Fakih Chokri Mohammed Ben Lamine Marwan Shaheen Mahmoud Aljurf
Jul 2026 · Bone Marrow Transplantation · 0 citations · 29 references
Medicine

TL;DR

The data support NMA and RIC transplantation as genuinely curative options carrying an acceptable risk profile for adults living with SCD, and advances in haploidentical conditioning have largely put to rest the graft failure rates that once made unrelated or mismatched transplantation prohibitive.

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