Background and objectives: Asthma is a globally significant non-communicable disease with major public health consequences. Objective of this study was to find out the association between serum uric acid levels and severity of airflow obstruction, to measure the serum uric acid in asthma patients and to determine the severity of asthma by FEV1.
Methodology: This cross sectional study was done in the National Institute of Diseases of the chest & Hospital (NIDCH), Mohakhali and total 110 study population who fulfilled the GINA 2019 criteria for the diagnosis of asthma in adults with e” 18 years were included. Patient with smoking, other obstructive lung diseases, gout or F/H of hyperuricemia, chronic kidney disease, hepatic failure, active malignancies or acute gastrointestinal bleeding, IHD, patients treated with diuretics and xanthine derivatives (e.g. theophyline) and pregnancy were excluded.
Results: Mean serum uric acid level 6.76 mg/dl (±0.53 mg/dl) is found significantly higher among obese patient than non-obese patients. The most common trigger was ongoing URTI. Among the participants, 24 (21.8%) had well controlled symptoms. 59 (53.6%) had partly controlled symptoms and 27 (24.6%) had uncontrolled symptoms. Significantly higher serum uric acid level was also observed in patient with partially controlled and uncontrolled asthma when compared with well controlled asthma. Significantly higher serum uric acid level was found in patient with more severe airflow obstruction when compared less severe airflow obstruction
Conclusions: Higher serum uric acid levels are associated with higher severity of asthma and poor asthma control.
Chest Heart J. 2023; 47(1) : 34-39
Leema Saha, H. Saha, Swadesh Kumar Saha et al.· Chest & Heart Journal· 0 citations
Background: Chronic obstructive pulmonary disease (COPD) is thought to have increased association with metabolic syndrome (MS) which represents a cluster of factors that increase the risk of cardiovascular diseases and diabetes mellitus. However, the extent of association of COPD with MS and its individual components are still an unsettled issue, and it is likely to vary from population to population. This study was undertaken to assess association of COPD with metabolic syndrome.
Methods: This cross-sectional study conducted at the Department of Respiratory Medicine in National Institute of Diseases of the Chest and Hospital from January 2019–December 2019. A total of 91 patients with chronic obstructive pulmonary disease (COPD) were enrolled in this study.
Results: Out of 91 patients with COPD, more than one third (34.1%) patients were belonged to age 51-60 & 61-70 years respectively with mean age 60.4±10.9 years ranging from 42 to 90 years. Majority (85.7%) patients were male. Male to female ratio was 6:1. Twenty seven (29.7%) were service holder and most of the patients 76(83.5%) were smoker. Mean BMI was 20.6±4.0 kg/m2, mean waist circumference was 86.9±6.8 cm, mean SBP 120.1±17.5 mmHg and mean DBP 76.3±11.1 mmHg. Mean FEV1/FVC post bronchodilator was 51.2±9.5 percent. Mean triglycerides was 149.9±38.4 mg/dl, mean HDL-C was 39.4±9.8 mg/dl, mean fasting glucose was 104.1±28.0 mg/dl. Metabolic syndrome was found in 19(20.9%) patients. Age, sex, occupational status, smoking, BMI, waist circumference, hypertension, triglycerides, HDL-C, fasting glucose and metabolic syndrome were not statistically significant (p>0.05) when compared grade of COPD.
Conclusion: In conclusion, the present study demonstrated that metabolic syndrome present in 20.9% of COPD patients. Age, sex, occupational status, smoking, BMI, waist circumference, hypertension, triglycerides, HDL-C, fasting glucose and metabolic syndrome were not statistically significant when compared grade of COPD. Thus, considering COPD as a systemic disease and screening for components of metabolic syndrome could form a part of routine work-up of these patients.
Chest Heart J. 2022; 46(1) : 10-17
Mohammad Ezazul Karim, K. C. Ganguly, Bipul Kanti Biswas et al.· Chest & Heart Journal· 0 citations
