Association between Serum Uric Acid and Severity of Airflow Obstruction in Asthma

Abstract

Background and objectives: Asthma is a globally significant non-communicable disease with major public health consequences. Objective of this study was to find out the association between serum uric acid levels and severity of airflow obstruction, to measure the serum uric acid in asthma patients and to determine the severity of asthma by FEV1. Methodology: This cross sectional study was done in the National Institute of Diseases of the chest & Hospital (NIDCH), Mohakhali and total 110 study population who fulfilled the GINA 2019 criteria for the diagnosis of asthma in adults with e” 18 years were included. Patient with smoking, other obstructive lung diseases, gout or F/H of hyperuricemia, chronic kidney disease, hepatic failure, active malignancies or acute gastrointestinal bleeding, IHD, patients treated with diuretics and xanthine derivatives (e.g. theophyline) and pregnancy were excluded. Results: Mean serum uric acid level 6.76 mg/dl (±0.53 mg/dl) is found significantly higher among obese patient than non-obese patients. The most common trigger was ongoing URTI. Among the participants, 24 (21.8%) had well controlled symptoms. 59 (53.6%) had partly controlled symptoms and 27 (24.6%) had uncontrolled symptoms. Significantly higher serum uric acid level was also observed in patient with partially controlled and uncontrolled asthma when compared with well controlled asthma. Significantly higher serum uric acid level was found in patient with more severe airflow obstruction when compared less severe airflow obstruction Conclusions: Higher serum uric acid levels are associated with higher severity of asthma and poor asthma control. Chest Heart J. 2023; 47(1) : 34-39