Author

Morgan D. Fullerton

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Open access Sep 2026

Casp1 and Ripk3 are required for homeostatic insulin secretion in mice

Objectives Cell death and inflammatory pathways play important roles in adaptations to nutrient overload and metabolic dysfunction. This study investigates the metabolic consequences that arise from the dual disruption of both caspase 1 (Casp1) and receptor interacting protein kinase 3 (Ripk3) in mice fed a control or...

Madison D. Girouard, Conor O'Dwyer, C. Locatelli et al. · bioRxiv · 0 citations

#protein folding Open access Oct 2026

SPRIZ (CCDC127) protein conserved in deuterostome animals is a rigid OMM–IMM tether that locally sets mitochondrial IMS volume

The double-membrane nature of mitochondria generates an intermembrane volume through which ions, reactive oxygen species, and metabolites must flux to reach the matrix or cytosol, but whether this volume is a genetically specified structure remains unknown. We identify SPRIZ (spatial regulator of the intermembrane zone...

Raman Shulinski, Roman Loban, Danny Farhat et al. · Science Advances · 0 citations

Open access Sep 2026

AMPKα regulates glycolytic reprogramming to sustain NK cell proliferation and effector function

Natural killer (NK) cells are critical innate lymphocytes that mediate early anti-viral immunity through cytotoxicity and cytokine production. Activation of NK cells require metabolic reprogramming to sustain proliferation and effector functions; however, the molecular regulators coordinating this process remain inco...

A. Khan, Jannat Pervin, Safa Ghaziasgar et al. · Cell Death & Disease · 0 citations