Author

N. Bediaga

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Jul 2026

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

It is shown that DNMT1 is enriched at unmethylated CpG islands of actively transcribed genes largely by its CXXC domain, and RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promoting the suppression of endogenous retroviral element-dependent viral mimicry.

Brian J. Liddicoat, Jesse J. Balic, W. Jia et al. · Nature Genetics · 1 citation

#gene editing Open access Jul 2026

Prime editing enables drug-controllable T-cell therapies with clinical immunosuppression.

A multiplex prime-editing platform is developed that converts commonly used immunosuppressive drugs into tools for in vivo control of T-cell therapies via defined, pathway-specific drug resistance, enabling selective in vivo modulation in settings where immunosuppression cannot be withdrawn.

E. Bandala-Sanchez, Emma V. Petley, K. Ramsay et al. · Blood · 0 citations