Author

N. Benvenisty

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Open access Jul 2026

Analysis of haploinsufficiency in human neural progenitor cells: insights into early molecular effects of autism-related genes.

This work differentiated a genome-wide heterozygous loss-of-function CRISPR library into neural progenitor cells (NPCs) and defined about 250 genes essential for neural differentiation in a haploinsufficient manner, and offers new insights into the embryonic molecular basis of ASD and other NDDs driven by gene dosage imbalance.

Roni Sarel-Gallily, Assa Sherman, Daniel Pollak et al. · Cell Death and Disease · 1 citation

#protein folding Open access Aug 2026

Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties

This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantation is demonstrated.

I. Gruh, Andreas Martens, S. Cebotari et al. · Nature Communications · 0 citations