N. Kaminski

Multi-omics reveals a monocyte-macrophage-fibroblast axis in post-COVID-19 fibroinflammatory lung remodelling

Single-cell and spatial transcriptomics resolve airway obliteration in bronchiolitis obliterans syndrome

BOS engages structural-cell circuits largely shared with RAS and fibrotic lung diseases, but along an airway-centered rather than parenchyma-centered axis, and shared structural programs may therefore be targetable across CLAD phenotypes.

Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts

It is concluded that mTORC1 plays a key role in shaping the transcriptional identity of these fibroblasts, with implications for therapeutic inhibition of mTORC1 in fibrosis and cancer.

Aberrant and Ectopic Cell Populations in Restrictive Allograft Syndrome after Lung Transplantation.

Considering the multifaceted differences of RAS and idiopathic pulmonary fibrosis, a surprising general principle of an entity-spanning composition of the fibrotic niche by aberrant basaloid cells localized at the fibrotic edge, ectopic COL15A1+ pVECs and CTHRC1+ fibrotic fibroblasts is revealed.