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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

N. Seyfried

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#gene editing Open access Oct 2026

The Alzheimer’s disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health

Background Loss of function mutations in the lipid transporter ABCA7 have been linked to increased risk for late onset Alzheimer’s disease (AD). Although rare and common variants in ABCA7 associated with AD alter the coding sequence and are predicted to impair protein function, the precise cell-type consequences of ABC...

Sarah E. Heuer, Fasiha Ahsan, Gizem Terzioglu et al. · 0 citations
Open access Aug 2026

Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis

Background Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are components of the amyloid deposits in Alzheimer’s disease (AD) and other amyloidoses. HS and HSPGs are canonically thought to facilitate amyloid deposition by accelerating the aggregation of amyloidogenic proteins and impairing their clearanc...

K. Shim, Yong Ran, Danny Ryu et al. · 0 citations
Open access Sep 2026

TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD

This work identifies a novel molecular mechanism for TDP-43 dysfunction, opening novel avenues for understanding disease pathogenesis and developing much needed pathology biomarkers.

Dario Dattilo, F. Pellegrini, Simone Barattucci et al. · 0 citations
Open access Aug 2026

Multi-omics comparative analyses of synucleinopathy models reveal distinct drug targets and relevance for drug development

The set of disrupted proteins/genes were compared to that aberrantly expressed in human PD and dementia with Lewy bodies and candidate drug targets in a “PD drug development pipeline”, revealing potential disease biomarkers and optimal models for testing novel therapeutics.

Britney N. Lizama, Rick Shin, Hilary A. North et al. · 0 citations

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