N. Singla

Is a Few Too Many? Alcohol Consumption and Prostate Cancer Upgrading During Active Surveillance.

BACKGROUND The association between alcohol consumption and prostate cancer (PCa) outcomes remains mixed, with particularly limited data on the association between alcohol consumption and risk of upgrading among men undergoing active surveillance (AS). METHODS We analyzed men with Grade Group (GG) 1 PCa managed in a p...

Development and internal validation of machine-learning models to predict adverse pathological features in upper tract urothelial carcinoma.

BACKGROUND Accurate preoperative staging and identification of adverse pathological features in upper tract urothelial carcinoma (UTUC) remain contemporary challenges. We aimed to develop and internally validate machine-learning (ML) models to predict muscle-invasive (≥pT2) and lymph node positive (pN+) disease using p...

Spatial distribution and prognostic significance of hemorrhagic imaging features in brain metastases from metastatic renal cell carcinoma

59 GPNMB:CD44 Signaling Drives Tumor Progression in Translocation Renal Cell Carcinoma

Abstract Background MiT/TFE-rearranged, translocation renal cell carcinoma (tRCC) is characterized by gene fusions involving TFE3 or TFEB, and is a rare, aggressive non-ccRCC, often occurring in children and with few biomarkers or targeted therapy options. TFE3 is the most commonly translocated gene with ASPSCR1, PRCC...