Scalable proteomics with multiDIA resolves proteoforms in neurodegenerative disease
Deep proteome characterization has traditionally required multidimensional chromatographic fractionation, long acquisition times and large sample amounts, thus limiting scalability. Here, we introduce multiDIA, which combines independent digestions with multiple proteases and data-independent acquisition (DIA) to incre...
Orhun Kok, Corinna Friedrich, Kirsten Altig et al.
· bioRxiv · 0 citations