Author

N. Thomaidis

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Review Open access Sep 2026

Glymphatic Dysfunction Across Neurological disorders: Links to Neurodegeneration, Inflammaging, Gut–Brain Signaling, and Physiological Modulators

The glymphatic system is a brain-wide perivascular network that facilitates cerebrospinal-fluid–interstitial-fluid exchange and the clearance of metabolic waste. Growing experimental and clinical evidence suggests that glymphatic dysfunction may represent a convergent pathophysiological feature associated with aging, n...

Konstantinos I. Voumvourakis, N. Thomaidis, Eleni Sideri et al. · Biomedicines · 0 citations

#protein folding Open access Sep 2026

Harnessing coumarin privilege to achieve potency and selectivity: hypoxia-targeted alkyl coumarin-tethered phenyl quinazolinones as dual hCA IX/HSP90α inhibitors with chemosensitizing activity

A series of alkyl coumarin-tethered phenyl quinazolinones were rationally designed and synthesized as hypoxia-targeted dual hCA IX/HSP90α inhibitors, exhibiting potent, highly selective inhibition of hCA IX (in the nanomolar range), while displaying negligible activity against the off-target isoforms hCA I and II.

Amal S. Elgohary, Mervat H. El-Hamamsy, N. Sharafeldin et al. · RSC Advances · 0 citations