Author

Nacho Molina

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#protein folding Open access Oct 2026

Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains.

Chromosomes fold into distinct domains that regulate transcription, replication and repair. In addition to well-characterized topologically associating domains (TADs) and compartments, the diversity of heterochromatin domains remains poorly defined at the sequence level. Here, using single-molecule tracing of nascent h...

Dania Camila Pulido Barrera, J. E. You, Angelo L. Angonezi et al. · Nature Structural & Molecula... · 0 citations

Open access Sep 2026

Comparison of cell-cycle gene expression dynamics and mRNA kinetics across mouse and human pluripotent systems

Cell-cycle remodeling is fundamental to pluripotency and lineage commitment, yet whether its transcriptional and post-transcriptional architecture is conserved across species and developmental states has remained unresolved. Here we introduce Ciclopes, a biology-informed deep-learning framework that resolves continuous...

Maulik K. Nariya, David Santiago-Algarra, Gianni Zanardelli et al. · bioRxiv · 0 citations