Nese Basak Turkmen

Maternal Plasma Proteomic Signatures Distinguish Preeclampsia from Healthy Pregnancy but Not Early-Onset from Late-Onset Subtypes: A Leakage-Free Machine-Learning and Explainability Study

Early-onset (EOPE) and late-onset (LOPE) preeclampsia are clinically distinct, but their molecular differences are incompletely defined. Using a strictly leakage-free pipeline, we re-examined maternal plasma proteomes of EOPE, LOPE, and healthy pregnancy (HP) and asked whether the subtypes are separable at the proteome...