Author

Nicholas M. I. Taylor

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Open access Sep 2026

Non-canonical cleavage of GPR125/ADGRA3 releases extracellular receptor fragments detectable in cerebrospinal fluid

Summary Adhesion G protein-coupled receptors (aGPCRs) are crucial for barrier tissues and typically autoproteolytically cleaved into N- and C-terminal fragments (NTF and CTF) that remain non-covalently associated until separation is triggered. Here, we show that human GPR125 (ADGRA3), expressed in choroid plexus epithe...

Anna L. S. Walser, O. Larsen, Chiara Stüdle et al. · iScience · 0 citations

#protein folding Open access Sep 2026

Piercing mechanism in the minimal contractile tail of bacteriophage P2

A previously undescribed fold is identified in the head-to-tail adaptor, which mediates the transition from 12-fold portal symmetry to sixfold tail symmetry through interlocking β-strand “handshake” interactions and support a distinct model of contractile tail activation and expand the known architectural diversity of...

Victor Klein-Sousa, M. Šiborová, A. Roa-Eguiara et al. · bioRxiv · 0 citations