Summary Despite ribosomal protein loss correlating with increased tumor predisposition, direct mechanisms for the counterintuitive oncogenic effect of ribosomal protein depletion have not been reported. We used genetic models to investigate ribosomal protein S19a (RpS19a) depletion in the Drosophila blood organ, the ly...
Naomi C. Mitchell, Arjun S. Chahal, T. Javaid et al.· iScience· 0 citations
Background Long-read sequencing platforms, particularly Oxford Nanopore Technologies (ONT), have transformed transcriptomics through direct RNA sequencing. However, their higher error rates – dominated by insertions and deletions – demand longer, more robust sequence barcodes. Existing barcode generation tools suffer...
F. Chowdhury, Tessa Swain, Roderik Shirokikh et al.· F1000Research· 0 citations
It is proposed that early replication and protein biosynthesis were inseparable functions performed by a single ancient RNA molecule: the riboreplisome, and this hypothesis addresses fundamental challenges facing RNA world, protein world, and RNA-protein co-evolution theories.
Alice Cleynen, Archa H. Fox, Nikolay E. Shirokikh· 0 citations
It is shown that the repressed glycosylation program is distinguished by a convergent stack of independent cis-regulatory signatures: weak Kozak initiation context, high upstream open reading frame burden, excess RNA secondary structure specifically over the start codon, and depletion for the targets of major stabilisi...
O. Rossini, S. Mahmud, Nikolay E. Shirokikh et al.· bioRxiv· 0 citations
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