Aug 2026
STINGing the brain: S-nitrosylation drives neuroinflammation in Alzheimer's disease.
Neuroinflammation is a major secondary driver of Alzheimer's disease (AD). In this issue of Cell Chemical Biology, Carnevale et al.1 demonstrate that S-nitrosylation of the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway sustains pathological neuroinflammation in AD, identifying a promising therapeutic target for this devastating disease.
Andrew A. Pieper, Emiko Miller, O. Khalimonchuk et al.
· Cell Chemical Biology · 0 citations