Aug 2026· Cell Chemical Biology· Vol 33 8, pp.
1065-1067
· 0 citations· 11 references
Medicine
TL;DR
It is demonstrated that S-nitrosylation of the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway sustains pathological neuroinflammation in AD, identifying a promising therapeutic target for this devastating disease.
Abstract
Neuroinflammation is a major secondary driver of Alzheimer's disease (AD). In this issue of Cell Chemical Biology, Carnevale et al.1 demonstrate that S-nitrosylation of the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway sustains pathological neuroinflammation in AD, identifying a promising therapeutic target for this devastating disease.
A variety of evidence now supports two interrelated hypotheses concerning Alzheimer’s disease (AD) neurofibrillary pathology (NFT), its prevention and treatment. The first hypothesis: the receptor type protein tyrosine phosphatase D (PTPRD) plays a key role in AD NFT pathogenesis by modulating activities of neuronal gl...
George R. Uhl, Joungil Choi, B. Kannan et al.· Biomedicines· 0 citations
The Journal retracts the article "Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson's Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment" [...].
Abubakar Atiq, Hyeon Jin Lee, Amjad Khan et al.· International Journal of Mol...· 0 citations
Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive decline and behavioral impairments. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that exerts pleiotropic neuromodulatory, anti-inflammatory, cytoprotective, and trophic effects within the centr...
Martina Bodria, Eleonora Daini, Stefano Pioli et al.· Brain Science· 0 citations
Parkinson's disease (PD) is one of the common neurodegenerative diseases and is difficult to cure. The mechanisms underlying PD are incompletely understood.
Neuroinflammation is currently considered the most advanced and comprehensive concept that explains the pathogenesis of a wide range of neurological diseases, from Alzheimer's disease and multiple sclerosis to depression and cognitive impairments. In this context, the role of oxidative stress in initiating and maintain...
T. Sorokovikova, L. Chichanovskaya, O. Pavlova et al.· Vrach· 0 citations
its pleiotropic pharmacology, CHX should be regarded here as a nonselective pharmacological probe rather than a repurposing-ready AD therapeutic. That said, the effect does not appear to be simply broad, nonspeci fi c suppression. Components of the γ -secretase complex were unchanged by CHX, and the reduction in gliosis...
Jinsu Park, H. Bae, Yoonsuk Cho et al.· Signal Transduction and Targ...· 0 citations
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