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Author

Bindu D. Paul

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3 papers indexed here

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Open access Sep 2026

Biliverdin reductase A deficiency reveals sex- and brain region-specific vulnerability to high-fat diet feeding

How the brain senses and responds to early metabolic stress, and why this process fails differently across sexes and regions, remains poorly understood. Here we show that biliverdin reductase A (BVRA) loss is associated with sex- and brain region-specific effects in response to high-fat diet (HFD) feeding, impairing in...

Simona Lanzillotta, V. Sommella, Barbara Zulli et al. · 0 citations
#protein folding Open access Sep 2026

Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia

It is demonstrated that loss of membrane-bound catechol-O-methyltransferase (MB-COMT), a key degrader of DA in the brain, disrupts cellular metal handling and redox-regulatory pathways and triggers widespread protein misfolding in schizophrenia and Parkinson’s disease.

S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al. · 0 citations
Aug 2026

STINGing the brain: S-nitrosylation drives neuroinflammation in Alzheimer's disease.

It is demonstrated that S-nitrosylation of the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway sustains pathological neuroinflammation in AD, identifying a promising therapeutic target for this devastating disease.

A. A. Pieper, Emiko Miller, O. Khalimonchuk et al. · 0 citations

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