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Océane Marescal

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#protein folding Open access Oct 2026

Functional genetics reveals a role for the proteasome in regulating centromere assembly

Centromeres link chromosomes to spindle microtubules to direct their segregation during mitosis. The vertebrate centromere is built on two critical DNA-binding proteins, the histone H3-variant CENP-A and histone fold protein CENP-T. CENP-T is a potent scaffold for kinetochore assembly, such that concentrating it at ect...

Océane Marescal, Kuan-Chung Su, Matteo Di Bernardo et al. · 0 citations
Open access Jul 2026

A machine learning model predicts protein stability of annotated and alternate protein isoforms

The regulation of protein stability is essential for cellular homeostasis and is determined by a combination of intrinsic sequence motifs and extrinsic recognition enzymes. Despite growing knowledge of the protein degradation machinery, the ability to predict a protein’s stability from its amino acid sequence remains c...

Océane Marescal, Iain M. Cheeseman · 0 citations

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