Author

Orna Dahan

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Open access Oct 2026

A massively parallel reporter screen defines the syntax of SECReTE, a secretion-enhancing cis regulatory targeting element, in mammalian cells

Messenger RNA (mRNA) localization to specific subcellular regions is crucial for proper protein translation and localization. Potential means to localize mRNAs include cis-acting or structural motifs embedded within the sequence. We previously identified a secretion-enhancing cis regulatory targeting element (SECReTE)...

Gal Haimovich, Gabriela Lobinsky, Shu-Ting You et al. · bioRxiv · 0 citations

Sep 2026

Encoded and non-genetic protein variants expand human functional proteome.

It is found that the abundance of both genetic and mistranslated protein variants mirrors their allele frequencies in the human population, and it is proposed that non-genetic amino acid substitutions in human proteins provide an abundant source to expanding the functional proteome.

Vyacheslav Tretyachenko, Tehila Leiman, David Morgenstern et al. · Nature · 1 citation

Open access Jul 2026

Evolution of a genome-architecture-encoded gene regulation system in trypanosomatids

Findings reveal an evolutionary shift from gene-specific transcriptional regulation toward a regime where genome architecture becomes a regulator of gene expression.

Saurav Mallik, Meir Sylman, Moshe Kafri et al. · bioRxiv · 0 citations