Encoded and non-genetic protein variants expand human functional proteome.

Vyacheslav Tretyachenko Tehila Leiman David Morgenstern Yishai Levin Omer Asraf Orna Dahan Dvir Dahary Y. Pilpel

Sep 2026 · Nature · 1 citation

Medicine

TL;DR

It is found that the abundance of both genetic and mistranslated protein variants mirrors their allele frequencies in the human population, and it is proposed that non-genetic amino acid substitutions in human proteins provide an abundant source to expanding the functional proteome.

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