Sep 2026
Encoded and non-genetic protein variants expand human functional proteome.
It is found that the abundance of both genetic and mistranslated protein variants mirrors their allele frequencies in the human population, and it is proposed that non-genetic amino acid substitutions in human proteins provide an abundant source to expanding the functional proteome.
Vyacheslav Tretyachenko, Tehila Leiman, David Morgenstern et al.
· Nature · 1 citation