Vitamin E Attenuates Glyphosate-Induced Multi-Organ Toxicity and Redox Imbalance in Rats: Biochemical and Histopathological Evidence
Simple Summary Glyphosate is the most widely used weed killer in the world. Farm animals, companion animals, and working animals can be exposed to it over long periods through feed, water, and grazing on treated pasture, which makes its safety a genuine veterinary concern. In this study, rats—a standard model for mammalian toxicity—received glyphosate for 30 days, and some were also given vitamin E, a natural antioxidant present in many feedstuffs. Glyphosate damaged several organs, including the liver, lungs, kidneys, testes, and heart. Although the blood markers of oxidant load did not rise as expected, the animals’ antioxidant defences increased and the tissue damage itself was consistent with oxidative injury. Co-treatment with vitamin E strengthened antioxidant capacity and protected the organs from much of the damage. These findings suggest that vitamin E may help limit the harmful effects of long-term glyphosate exposure in animals and could serve as a simple, protective dietary supplement.