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Author

P. Jaffrès

2 papers indexed here

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Open access Sep 2026

Influence of the lipid thioether modification and formulation method on lipoplex structure, stability and transfection efficiency in HEK293T cells.

Lipoplexes, formed by electrostatic interactions between nucleic acids and cationic lipids, must protect their cargo, enable cellular uptake and promote intracellular release for non-viral gene delivery. Although traditionally produced by bulk complexation, scalable microfluidic methods are now available. However, how...

M. Rochedy, Laurie Dechamboux, A. Dupont et al. · 0 citations
#gene editing Open access Sep 2026

Lipid nanoparticle induced model endosomal membrane disruption

This study uses giant unilamellar vesicles mimicking the endosomal membrane to directly visualize the interaction and membrane disruptions caused by two model LNPs constituted by two different ionizable lipids, establishing a cell-free platform for dissecting individual sub-steps of endosomal escape.

Shreya Pramanik, Aishwarya Vasudevan, Zheng-Hua Liang et al. · 0 citations

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