Author

P. Kielkowski

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Open access Aug 2026

Chemoproteomics identifies a pyrimido[4,5-d]pyrimidine analogue as a tubulin-tyrosine ligase binder

This work serendipitously identified CEM198 as the first high-affinity ligand of tubulin-tyrosine ligase (TTL), introducing CEM198 as a chemical probe for investigating the tubulin tyrosination–detyrosination and demonstrating the potential of chemoproteomics to uncover novel modulators of microtubule dynamics.

Rubaba R. Abanti, Eleftheria A. Georgiou, D. Makarov et al. · bioRxiv · 0 citations

Open access Aug 2026

Activity-based chemical proteomics uncovers unexpected covalent targets of E64d and reveals a role for cysteine cathepsins in PLD3 proteostasis

In neurons, treatment with E64d lead to about 50-fold PLD3 accumulation and dysregulation of its proteolytic cleavage, while there was only a minor overall change on the whole proteome level, which suggests that their activation might be responsible for decreased PLD3 levels in neurons of patients with Alzheimer’s dise...

Manuel Hertwig, P. Kielkowski · bioRxiv · 0 citations

Open access Aug 2026

A Scalable and Robust Workflow for Cost-Effective Post-Translational Modifications Profiling by Chemical Proteomics

Mass spectrometry-based chemical proteomics is a powerful method to analyze proteins labelled by small molecules to identify protein targets of active compounds and to profile protein post-translational modifications. The throughput and high protein input for chemical proteomics workflows has been often a limiting fact...

Liu Zang, Jonas Grandke, Jana Richter et al. · bioRxiv · 0 citations