Efficacy Is Impacted by
Dual MEK and mTORC1/2 blockade resulted in synergistic antiproliferative effects in cell lines bearing alterations in KRAS/BRAF and PIK3CA/PTEN and a marked proapoptotic response to therapy was observed exclusively in wild-type TP53 colorectal cancer models.
Celina García-García, M. Rivas, Y. Ibrahim et al.
· 0 citations