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Efficacy Is Impacted by

Celina García-García M. Rivas Y. Ibrahim M. Calvo Albert Gris-Oliver O. Rodríguez J. Grueso Pilar Antón M. Guzman C. Aura P. Nuciforo Katti A. Jessen G. Argilés R. Dienstmann A. Bertotti L. Trusolino J. Matito A. Vivancos I. Chicote Héctor G. Palmer J. Tabernero M. Scaltriti J. Baselga V. Serra
· 0 citations · 27 references

TL;DR

Dual MEK and mTORC1/2 blockade resulted in synergistic antiproliferative effects in cell lines bearing alterations in KRAS/BRAF and PIK3CA/PTEN and a marked proapoptotic response to therapy was observed exclusively in wild-type TP53 colorectal cancer models.

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