Patcharapitcha Pechkamnerd

ClpXP Overexpression Boosts Mitochondrial Protein Degradation, Organismal Health, and Longevity Without Altering Stress Response in D. melanogaster

Mild overexpression of clpX and clpP resulted in a significant increase in climbing ability during adulthood and a small increase in longevity, suggesting that mild increases in mitochondrial protein degradation, independent of stress response pathway activation, can be sufficient to improve a marker of health and exte...