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ClpXP Overexpression Boosts Mitochondrial Protein Degradation, Organismal Health, and Longevity Without Altering Stress Response in D. melanogaster

Camille Goldman Chadinthon Kittivorawong Samantha Salazar Paul M. Oh Kristofer Chang Muhammad Jalal Patcharapitcha Pechkamnerd Tracy Han Aly Rajan Joshua Zhong Malina DiBlasi Jae Hur
Aug 2026 · bioRxiv · 0 citations · 90 references
Biology

TL;DR

Mild overexpression of clpX and clpP resulted in a significant increase in climbing ability during adulthood and a small increase in longevity, suggesting that mild increases in mitochondrial protein degradation, independent of stress response pathway activation, can be sufficient to improve a marker of health and extend lifespan.

DOI Semantic Scholar
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