This work resolves the long-standing ambiguity between TBC1D15 total expression level and its subcellular shuttling, establishing a new conceptual framework that prioritizes protein translocation over bulk abundance in organelle quality control.
Peng-Fei Qiang, Yan Li, Shuang Liang et al.· Cells· 0 citations
Evidence is synthesized that CD44, through its structural domains, isoform diversity, and proteolytic processing, integrates extracellular cues to modulate key pathways to modulate key pathways such as STAT3, NF-κB, and the class III PI3K complex.
