Pengfei Yang

Endovascular treatment after stroke beyond 24 h vs 6-24 h: a propensity score-matched cohort study.

BACKGROUND Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke due to anterior circulation large vessel occlusion (LVO) within 6-24 h. However, the safety and feasibility of EVT for anterior circulation strokes beyond 24 h remain uncertain. METHODS We conducted a retrospective cohort s...

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

This review provides a structured synthesis that spans from the biological basis of mitochondrial function and transfer to the broad applications of nanomaterials in mitochondria‐targeted therapies, with a dedicated analysis of their roles in mitochondrial targeting, functional modulation, and gene editing.

Ketone Bodies in Ischemic Stroke: A Review of Neuroprotective Mechanisms and Therapeutic Implications.

Ischemic stroke disrupts cerebral metabolism and initiates a cascade of pathological events, including excitotoxicity, mitochondrial dysfunction, and neuroinflammation. These interconnected processes drive neuronal apoptosis, necrosis, and synaptic loss, ultimately leading to irreversible brain injury, persistent neuro...

Feasibility of a novel multi-device robotic system for multiple neurointerventional procedures: pre-clinical validation in porcine models