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Peng Lei

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Open access Aug 2026

Poly (Lipoic Acid) Nanoparticles With High Blood-Brain Barrier Permeability and Enhanced Anti-Ferroptotic Activity for Ischemic Stroke Treatment.

Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half-life and weak efficacy in penetrating the blood-brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half-life of more than 15 h and a high effici...

Qing-Zhang Tuo, Juan Tan, Hong-Fa Yan et al. · 0 citations
Aug 2026

XunZi, an AI biologist, reveals disease-modifying targets.

In Parkinson's disease (PD), where complex mechanisms and limited targets hamper therapy development, XunZi identifies aberrant activation of CHK2 and IRAK4 kinases across multiple models and establishes a paradigm-shifting framework to translate fragmented biomedical knowledge and data into actionable therapeutics.

Xinhe Huang, Junhong Qin, Fei Tang et al. · 0 citations

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