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MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants.

Guangtong Jiang Dan-Ni Wang Lin Shao Xinru Mao Xiao-Peng Xiong Deng-Hong Zhang Win-Ning Chen Huilong Yuan Shijia Wang Jian Zhang J. Piña-Crespo Li Zhong Yun-wu Zhang Jie Zhang Huaxi Xu Ming Chen Timothy Y. Huang Xi-Lin Wu Peng Lei Ying-Jun Zhao
Jul 2026 · Molecular Psychiatry · 0 citations · 45 references
Medicine

TL;DR

Findings identify circTau6/cTau4R as a post-transcriptional mechanism that modulates tauopathy and partially recapitulated molecular signatures observed in human tauopathic brains.

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