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Pengfei Fang

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#protein folding Sep 2026

Leveraging Protein Dynamics for Selective Inhibition of Threonyl-tRNA Synthetase by Obafluorin Analogs.

A structure dynamics-based design strategy is reported that transforms OB into a selective antibacterial agent through rational modification of the nitrophenyl moiety, and establishes a 'kinetic sensor' strategy for achieving species selectivity.

Zilu Wang, Zheng-Xuan Zhang, Mingyu Xia et al. · 0 citations