Author

Pim J. Huis In 't Veld

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Open access Aug 2026

CIP2A tetramerization is required for mitotic DNA repair

DNA lesions that persist in mitosis threaten genome stability. These lesions recruit TOPBP1-CIP2A, a complex crucial to tether and process damaged DNA on mitotic chromosomes. Importantly, CIP2A is synthetic lethal in BRCA1/2 mutant cancer cells. However, mechanistic insight into the function of CIP2A is lacking. Here w...

L. de Haan, Rebecca Schneeweiss, Marco Barazas et al. · bioRxiv · 0 citations

Review Aug 2026

Structure and function of the outer kinetochore

This Review focuses on how the handful of KMN complexes present at each microtubule-binding site achieves this complex regulation with high accuracy.

Andrea Musacchio, Pim J. Huis In 't Veld, Rae R. Brown et al. · Nature reviews. Molecular ce... · 1 citation