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Author

Pingchang Yang

2 papers indexed here

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Open access Sep 2026

Antigen-specific regulatory T cells eliminate cognate CD4 effector T cells through perforin, granzyme B, and Bim.

T cells (Tregs) maintain immune tolerance, yet how they selectively eliminate cognate CD4+ effector T cells remains unclear. We propose a co-activation-dependent elimination mechanism, conceptually akin to synthetic lethality. Using in vitro co-cultures, we show that simultaneous peptide-MHC II recognition by Tregs and...

Yan-Yu Ye, Hao-Yue Zheng, Jia-Qi Duan et al. · 0 citations
Review Jul 2026

Autophagy-nitric oxide reprogramming of immune metabolism: a potential avenue for asthma therapeutic advancement.

Asthma is a complex inflammatory disease where oxidative stress and immune metabolic dysfunction coexist. As master regulators of this interface, macroautophagy/autophagy and nitric oxide (NO) signaling govern immune polarization, metabolic flux, and mitochondrial integrity. While NO functions as a redox messenger that...

Sohrab Khan, A. Sammad, Philippe Madjirebaye et al. · 0 citations

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