Collagen targeting IL-12 combined with doxorubicin enhances the anti-tumor effect against osteosarcoma.
It is demonstrated that CBD-IL-12 exhibited 4-fold enhanced tumor accumulation compared to unmodified IL-12 and increased cytotoxic T cell infiltration by 2.2-fold within the immune-cold microenvironment in a mouse model of OS.
Takumi Matsuo, Laurine Noblecourt, Pooja Kaur et al.
· Journal of Controlled Releas... · 0 citations