Ertapenem Exposure Is Associated with Downregulation of Purine Biosynthesis Proteins and Inhibition of Biofilm Formation in Staphylococcus aureus
This study demonstrates that ertapenem exhibits potent antibacterial activity against S. aureus and is a potential inhibitor of biofilm formation, and implicates a novel aspect of ertapenem’s activity connected to the disruption of purine biosynthesis in S. aureus through targeted downregulation of FGAM synthase.
Anamika Singh, Surabhi Pandit, Pradeep Pant et al.
· ACS Omega · 0 citations