Author

Preethi H. Gunaratne

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Open access Sep 2026

Atlas-Guided Cell-Specific Transcriptomics Identifies Pathway-Level Remodeling of Human Hypothalamic CRH Neurons in Opioid Use Disorder

Opioid use disorder (OUD) disrupts hypothalamic stress signaling, yet the molecular state of human paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) neurons remains poorly defined. Using single-nucleus RNA sequencing of 343,819 human hypothalamic nuclei, we applied complementary human HYPOMAP/MapMyCel...

Lorna Barrall, Phillip Urbanczyk, Bruno Kluwe-Schiavon et al. · bioRxiv · 0 citations

Aug 2026

Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer.

Overall immune-cell composition was largely preserved despite differences in immune-cell distribution, spatial organization, and T cell clonality, and multi-cohort validation across complementary spatial and single-cell platforms identified consistent alterations in innate-adaptive immune organization in immunosuppress...

Shorook Naara, V. Kochat, Xiayu Rao et al. · Cell · 1 citation