CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.
A CAR T-cell approach targeting an intracellular oncoprotein WT1 presented across diverse HLA-II families is developed, establishing a framework for CAR therapies against intracellular antigens, extending potential CAR T-cell applications to new cancer types and patient populations.