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Hypoxia and epithelial to mesenchymal transition pathways are enriched in bladder tumor epithelium adjacent to tertiary lymphoid structures

Kartik Sachdeva Priyanka Yolmo Abdulhameed Abdulhamed G. Conseil Sadaf Rahimi David M. Berman K. Tyryshkin Roger Li D. R. Siemens M. Koti

Aug 2026 · bioRxiv · 0 citations · 38 references

Biology

TL;DR

Findings indicate that a pro-tumorigenic microenvironment associated with disease progression in bladder cancer exists within peri-tumoral TLS and potentially a factor underlying contrasting therapeutic associations potentially driven by live microbial versus targeted immunomodulatory therapy in NMIBC and MIBC.

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